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Intravascular large B-cell lymphoma
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Intravascular large B-cell lymphoma : ウィキペディア英語版
Intravascular large B-cell lymphoma

Intravascular large B-cell lymphoma (ILBCL), also referred to as angiotropic large-cell lymphoma,〔 angiotropic large-cell lymphoma,〔 intralymphatic lymphomatosis,〔〔 intravascular lymphomatosis,〔 and, less specifically, intravascular lymphoma〔〔 and malignant angioendotheliomatosis〔〔 is a rare form of lymphoma.
==Diagnosis==
ILBCL presents with variable non-specific symptoms, the most common of which are rash, neurologic symptoms, and B symptoms, such as fever, weight loss, and night sweats.〔〔〔〔 It may be difficult to diagnose in a timely manner.〔 The disease is rare, with a prevalence of 1 person per million.〔 There are two forms of the disease; a Western form that has a cutaneous variant, and a form that is more common in east Asia.〔
The diagnosis is established by the examination of tissue under the microscope (i.e. biopsy or autopsy) and immunohistochemical stains. Intravascular lymphomas have a large cell morphology, i.e. the malignant cells are two or more times the size of a normal lymphocyte, and typically have a prominent nucleolus.
Most intravascular lymphomas are of the B-cell lineage.〔〔 Most cases of intravascular lymphoma are caused by the infiltration of B-cells into the lumens of small blood vessels.〔

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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